![]() Hence the applied in silico strategy led us to identify novel fungicides. Similarly increased disease control was observed in pre-treated potato tubers. Moreover in vitro trials showed that inhibitory effects were enhanced with increase in concentrations. The compounds were found to inhibit mycelial growth of A. Based on virtual screening results twelve commercially available compounds were purchased and tested in vitro and in vivo. The three dimensional SDH model showed good stereo-chemical and structural properties. We employed computational methodologies to design new SDH inhibitors using homology modeling pharmacophore modeling and structure based virtual screening. Hence targeting Alternaria solani SDH enzyme could be efficient tool to design novel fungicides against A. ![]() The enzyme Succinate dehydrogenase (SDH) is a potential drug target because of its role in tricarboxylic acid cycle. ![]()
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